Polynucleotides 101: Why Everyone’s Talking About Skin’s New Best Friend
There’s a new buzzword floating around aesthetic clinics and beauty circles—and no, it’s not the latest TikTok trend or another K-beauty miracle. It’s polynucleotides. And while it might sound like something you studied (or slept through) in GCSE Biology, this skin-boosting treatment is quickly becoming a favourite for those in the know.
If you’re wondering why everyone’s suddenly whispering sweet nothings to their skincare specialist about regenerative injectables, we’ve got you covered. Let’s demystify the science, the benefits, and why polynucleotides are being hailed as the “glow-up” your skin never knew it needed.
What Are Polynucleotides—and Why Should You Care?
In short? Polynucleotides are injectable skin boosters that don’t just sit there looking pretty—they get to work.
They’re made from purified DNA fragments (usually derived from salmon—yes, really), and their job is to help your skin repair itself. Think of them as tiny repairmen that clock in when your skin starts getting tired, sluggish, or a little bit ‘meh’.
Once injected, polynucleotides work below the surface to:
- Boost collagen and elastin
- Improve hydration from the inside out
- Reduce fine lines and crepey texture
- Even out skin tone and texture
- Support healing (yes, even from things like sun damage or acne scars)
Unlike traditional fillers that add volume, these clever little molecules encourage your skin to regenerate, making them the ultimate skincare multitasker.
Why Are Polynucleotide Treatments Suddenly Everywhere?
There are a few reasons why polynucleotide treatments are trending harder than cold plunges and gua sha routines.
First off, more people are looking for subtle, natural-looking results. We’re no longer chasing that ‘frozen face’ effect—we want to look well-rested, hydrated, and glowy… as if we’ve just returned from a relaxing break in the south of France, not a 30-minute appointment with a syringe.
Second, polynucleotides are all about long-term skin health, not short-term cover-ups. They work with your body, not against it. And they don’t fill or freeze—they restore and refresh. Which is exactly what a lot of us are looking for right now.
Polynucleotides vs Fillers: What’s the Real Difference?
Not sure whether to go for your usual filler top-up or try this new skin saviour? Here’s a friendly comparison to help you decide.
| ✨ Feature ✨ | Polynucleotides | Dermal Fillers |
| Purpose | Skin regeneration and hydration | Volume replacement and sculpting |
| Texture | Light, gel-like and bio-compatible | Thick or soft, depending on treatment area |
| Mechanism | Stimulates your own collagen and elastin | Adds volume by physically filling an area |
| Best For | Tired, dull, ageing, or textured skin | Lips, cheeks, jawline, and folds |
| Results | Gradual glow-up over weeks | Instant plump and structure |
| Longevity | 6–9 months on average | 6–12 months depending on the product |
| Vibe | Soft, natural, glowy | Structured, defined, contoured |
💡 Pro tip: They also work brilliantly together. Many of our clients combine polynucleotides with light fillers or wrinkle-smoothing treatments for an ultra-bespoke, skin-first result.
Common Reasons People Explore Polynucleotide Treatment
Wondering if this is for you? You don’t need to wait until your 40s—or any particular milestone—to invest in your skin’s health. Many clients start exploring injectable skin boosters in their late 20s or early 30s, while others come in seeking help for long-standing skin concerns.
Here are some common reasons people go for it:
- “I just want my skin to look healthier.”
- “I’m not quite ready for fillers yet.”
- “I want to soften fine lines without looking ‘done’.”
- “My under-eyes are looking tired, no matter how much I sleep.”
- “Help, my skin feels dull—even with all the serums!”
Sound familiar? You’re not alone. Skin confidence is about feeling good in your own skin—and polynucleotide treatment is a gentle but powerful way to support that.
How Do Polynucleotide Injections Feel?
In a word? Manageable.
We use a tiny needle (you’ll barely feel it) and apply numbing cream beforehand to keep you comfortable. Most people describe it as a bit of a scratch followed by a light sting. You might notice slight redness or swelling after, but it’s nothing you can’t cover with a bit of concealer. Within 24–48 hours, most clients are back to their usual glow.
Treatments are typically done in a series of two to three sessions, spaced a few weeks apart, with maintenance appointments every six to nine months.
How to Maximise Your Results
Once you’ve committed to skin repair injections, here are a few simple tips to make the most of them:
- Stay hydrated. Think of polynucleotides like a sponge—they work better when your body is well watered.
- Use SPF daily. Sun exposure is the #1 cause of premature skin ageing. Protect that investment!
- Pair with good skincare. Medical-grade serums and moisturisers can help amplify your results.
- Avoid intense workouts for 48 hours. Your skin needs a moment to settle and get to work.
- Keep up with maintenance. Results are cumulative—the more consistent you are, the better your skin looks and feels.
The Bottom Line
Polynucleotide treatments are the new kid on the block—and we’re officially obsessed. They offer a more holistic, regenerative approach to skincare, helping you glow naturally without the need for drastic changes.
Whether you’re a first-timer or a seasoned aesthetics lover looking to dial it back a bit, polynucleotides are the quiet upgrade your skin will thank you for.
Ready to give your skin some love? Learn more about our polynucleotide treatment options at Look Lovely London, or chat to one of our lovely practitioners about your skincare goals. To make an appointment, please book online or call 020 3900 2756 and we can help devise a personalised treatment plan just for you.
