Stimulate Stronger Hair Growth with Polynucleotides, Exosomes, and Microneedling
Thinning hair. Receding hairlines. Patchy spots. If you’ve ever looked in the mirror and noticed more scalp than you’d like, you’re not alone — and you’re not without options. Advances in regenerative medicine have opened up a whole new world of hair restoration that doesn’t involve surgery or harsh chemicals. Three of the most promising treatments right now? Polynucleotides, exosomes, and microneedling.
At Look Lovely London, we’re passionate about offering non-invasive, evidence-based treatments that truly work — and these innovative therapies are rapidly becoming favourites for those seeking natural hair regrowth.
Let’s break down how these treatments work, how they can help stimulate hair follicles, and why combining them might just be your secret weapon to thicker, healthier locks.
What Causes Hair Thinning in the First Place?
Before we get into the solutions, it’s important to understand the problem.
Hair loss can be triggered by a wide range of factors — from genetics and hormonal shifts to stress, poor nutrition, and environmental damage. Whatever the root cause, the common denominator is usually this: a lack of optimal support at the follicular level.
When the hair follicles are damaged, inflamed, or deprived of nutrients and growth factors, they shrink and produce thinner, weaker hair — eventually stopping production altogether. The key to effective treatment is reactivating those dormant or weakened follicles and creating the ideal environment for hair to thrive.
Polynucleotides: Cellular Repair from the Ground Up
Polynucleotides (PNs) are the building blocks of DNA and RNA — and they’re fast becoming one of the most exciting tools in aesthetic and regenerative medicine. Originally derived from salmon DNA (don’t worry, it’s purified and entirely biocompatible), these molecules help stimulate cell regeneration and repair damaged tissue.
So, how do polynucleotides help with hair growth?
- Revitalise hair follicles: Polynucleotides promote tissue healing and stimulate fibroblasts — the cells responsible for producing collagen and elastin — helping to restore the environment around hair follicles.
- Reduce inflammation: Chronic inflammation in the scalp is one of the most common contributors to hair loss. PNs soothe the skin and reduce oxidative stress, making the scalp more hospitable for new growth.
- Improve blood flow: Better circulation means more oxygen and nutrients reach the follicles, helping them to function more effectively.
Polynucleotide injections are typically delivered directly into the scalp via microinjections — precise and targeted, this approach allows the regenerative benefits to be concentrated exactly where they’re needed most.
Exosomes: Next-Level Cell Communication
If polynucleotides are the construction materials, exosomes are the master architects. These tiny extracellular vesicles act like messengers between cells, delivering proteins, lipids, RNA, and growth factors that coordinate healing and regeneration.
Derived from stem cells, exosomes are completely cell-free — meaning you get all the regenerative power of stem cell therapy, without any of the associated ethical concerns or complications.
Exosomes for hair growth are powerful because they:
- Reawaken dormant follicles: By delivering a cocktail of bioactive molecules, exosomes can help “reset” inactive hair follicles and push them back into the active growth phase (known as the anagen phase).
- Stimulate collagen production: Healthy hair requires a healthy scalp, and exosomes support the underlying tissue by promoting collagen and elastin synthesis.
- Control inflammation: Like PNs, exosomes are potent anti-inflammatories, helping to calm the scalp and reduce follicular damage.
Exosome therapy can be administered via injection or combined with microneedling for enhanced absorption and penetration.
Microneedling: Enhancing Absorption and Natural Stimulation
If you’ve heard of microneedling for skin rejuvenation, you’ll know it works by creating thousands of tiny micro-injuries that trigger the body’s natural healing response. When used on the scalp, the process is just as powerful.
Here’s why microneedling boosts hair growth:
- Improves absorption: When paired with polynucleotides or exosomes, microneedling enhances the delivery of active ingredients directly into the scalp.
- Activates growth pathways: The micro-injuries themselves stimulate the production of platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF), all of which are key to hair regeneration.
- Increases collagen production: Collagen isn’t just for your skin — it’s vital for the strength and structure of the scalp, which in turn supports healthy follicles.
Typically, a microneedling device fitted with fine needles is gently passed over the scalp in targeted areas, either before or after applying a regenerative serum like exosomes or polynucleotides.
Why Combination Therapy Works Best
While each treatment has its merits, combining polynucleotides, exosomes, and microneedling provides a powerful synergistic effect. Think of it as a three-pronged approach:
- Microneedling primes the scalp, increasing blood flow and creating microchannels.
- Polynucleotides jumpstart tissue repair, calm inflammation, and support structural regeneration.
- Exosomes deliver a potent message of rejuvenation, instructing cells to proliferate, restore, and grow.
Together, they don’t just treat the symptoms — they target the cause of hair thinning at a cellular level.
What to Expect from Treatment
At Look Lovely London, we offer tailored treatment plans based on your unique scalp condition, medical history, and hair goals. Most clients benefit from a series of sessions, spaced a few weeks apart, followed by maintenance treatments throughout the year.
Here’s what a typical protocol might look like:
- Consultation and scalp analysis
- Microneedling session with topical application of exosomes
- Targeted injections of polynucleotides for deeper follicular stimulation
- Follow-up treatments every 2-4 weeks
You may start to notice results in as little as 6–8 weeks, with full benefits seen at around 3–6 months. There’s little to no downtime — just some mild redness or tenderness on the day of treatment.
Who’s It For?
These treatments are ideal for:
- Men and women with early to moderate hair thinning
- Clients seeking non-surgical alternatives to hair transplants
- Those suffering from stress-related shedding or postpartum hair loss
- Anyone looking to enhance hair density, thickness, and scalp health
And because they’re based on naturally occurring substances, there’s minimal risk of side effects.
The Future of Hair Restoration Is Here
The days of relying solely on medications or invasive procedures are over. With advanced regenerative therapies like polynucleotides, exosomes, and microneedling, it’s possible to restore hair growth in a safe, subtle, and effective way — all without surgery or synthetic drugs.
If you’re ready to get to the root of your hair concerns, book a consultation with us at Look Lovely London. We’re here to help you feel confident in your hair — and in yourself. To make an appointment, please book online or call 020 3900 2756 and we can help devise a personalised treatment plan just for you.
